The numerical modeling of the effect of wind direction and velocity over the air cooling of PV panels with heat sinks is realized. During the study, a random PV panel with typical characteristics was analyzed for three different wind directions—towards its back, towards its front and from the side. The analysis was realized on a fixed PV panel, oriented to the south, with an inclination of 45 degrees from the horizontal position. The accuracy of the numerical simulation was achieved by comparison with the experimental studies presented in the literature and by comparing the NOCT conditions. The numerical study is focused on different types of heat sinks attached to a typical PV panel. The fins were distributed both horizontally and vertically. A challenging task consisted in simulation of the real wind conditions around the PV panel by taking into account the entire air domain. The simulations were realized for air velocity vair from 1 m/s to 5 m/s, solar radiation of G = 1000 W/m2 and ambient temperature tair = 35 °C. The output parameters analyzed were the average temperature of PV panels and their power production. Although the lowest temperatures were achieved for the back wind, the cooling effect was more intense for the side wind. The other direction studied also determined the cooling of PV panels. The passive cooling solutions analyzed introduced a rise of maximum power production between 1.85% and 7.71% above the base case, depending on the wind direction and velocity.