It was my great honor to be invited as a respondent to the 2020 Russell Family Fellowship Research Conference Lecture by Adam Pryor, who gave a wonderful talk through which he built a new ethical foundation from the interaction between the traditional doctrines of the imago Dei, sin, and vocation in Christian theology and astrobiology aiming for integration beyond dialogue. In regard to his claim at the beginning of his argument that astrobiology is moving biology from being a descriptive science to a science based on first principles, I raised the issue whether science should be descriptive or prescriptive. To argue that we should not rely on the first principles too much in doing science, even if they might help, I mentioned that even the physicists, who prefer theories with beauty, have abandoned beautiful theories when they find some unexpected, apparent ugliness in nature. For example, Albert Einstein did not like quantum mechanics because he believed that nature has nothing to do with probability, and Fred Hoyle rejected Big Bang cosmology because his first principle was that the universe is static and eternal. However, empirical evidences have forced physicists to abandon some of their former first principles, which illustrates that it is quite hard to imagine a science based only on unchanging first principles.