E-resources
Peer reviewed
-
Aragonés, Nuria; Fernández de Larrea, Nerea; Pastor-Barriuso, Roberto; Michel, Angelika; Romero, Beatriz; Pawlita, Michael; Mayorgas-Torralba, Sara; Martín, Vicente; Moreno, Victor; Casabonne, Delphine; Castilla, Jesús; Fernandez-Tardón, Guillermo; Dierssen-Sotos, Trinidad; Capelo, Rocío; Salas, Dolores; Salcedo-Bellido, Inmaculada; Chirlaque, María Dolores; Brenner, Nicole; Pedraza, Manuela; Bessa, Xavier; Pérez-Gómez, Beatriz; Butt, Julia; Kogevinas, Manolis; del Campo, Rosa; de Sanjosé, Silvia; Waterboer, Tim; Pollán, Marina
Cancer epidemiology, August 2019, 2019-08-00, 20190801, Volume: 61Journal Article
•High seroreactivity to EBV proteins EBNA-1 and VCA-p18 was associated with risk of gastric cancer.•Seropositivity to EBV proteins EA-D, ZEBRA, EBNA-1 or VCA-p18 was not associated with gastric cancer risk.•Dose-response analyses can be useful to detect associations for highly prevalent exposures. In contrast to the recognized role of Helicobacter pylori in the etiology of non-cardia gastric cancer (GC), there is still insufficient epidemiological evidence for the involvement of Epstein-Barr virus (EBV) in gastric carcinogenesis. We aimed to evaluate the relation of antibody profile and antibody reactivity intensity against four individual EBV proteins to GC risk. We used information from 281 GC cases and 2071 age and sex frequency matched controls recruited in the frame of the MCC-Spain multicase-control study, between 2008 and 2013. Sociodemographic, lifestyle and environmental factors were assessed in face-to-face interviews. Antibody responses to four EBV proteins (EBNA-1, ZEBRA, EA-D, and VCA-p18) were analyzed by multiplex serology. Odds ratios (OR) and 95% confidence intervals were calculated by using logistic regression mixed models to evaluate the association of seropositivity and antibody reactivity against EBV proteins with GC, adjusting for GC risk factors. Stratified analyses by tumor location (cardia vs. non-cardia) and morphology (intestinal vs. diffuse) were done. Among controls, seropositivity for EA-D, ZEBRA, EBNA-1 and VCA-p18 was 85%, 91%, 97% and 99%, respectively. Even though seropositivity for none of the studied proteins was associated with a higher GC risk, increasing antibody reactivity against EBNA-1 and VCA-p18 was associated with higher OR of GC. This association was present for cardia and non-cardia cancer cases, and for intestinal and diffuse types. Our results support the hypothesis that EBV may play a role in GC etiology, and highlight the importance of evaluating specific antibodies and the dose-response relations when studying widespread infections.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.