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Zhang, Xinwen; Mahajan, Jignesh S.; Zhang, Jinglin; Korley, LaShanda T.J.; Epps, Thomas H.; Wu, Changqing
Food and chemical toxicology, August 2024, Volume: 190Journal Article
Lignin-derivable bisguaiacols/bissyringols are viable alternatives to commercial bisphenols; however, many bisguaiacols/bissyringols (e.g., bisguaiacol F BGF) have unsubstituted bridging carbons between the aromatic rings, making them more structurally similar to bisphenol F (BPF) than bisphenol A (BPA) – both of which are suspected endocrine disruptors. Herein, we investigated the estrogenic activity (EA) and developmental toxicity of dimethyl-substituted bridging carbon-based lignin-derivable bisphenols (bisguaiacol A BGA and bissyringol A BSA). Notably, BSA showed undetectable EA at seven test concentrations (from 10−12 M to 10−6 M) in the MCF-7 cell proliferation assay, whereas BPA had detectable EA at five concentrations (from 10−10 M to 10−6 M). In silico results indicated that BSA had the lowest binding affinity with estrogen receptors. Moreover, in vivo chicken embryonic assay results revealed that lignin-derivable monomers had minimal developmental toxicity vs. BPA at environmentally relevant test concentrations (8.7–116 μg/kg). Additionally, all lignin-derivable compounds showed significantly lower expression fold changes (from ∼1.81 to ∼4.41) in chicken fetal liver tests for an estrogen-response gene (apolipoprotein II) in comparison to BPA (fold change of ∼11.51), which was indicative of significantly reduced estrogenic response. Altogether, the methoxy substituents on lignin-derivable bisphenols appeared to be a positive factor in reducing the EA of BPA alternatives. Display omitted •Bissyringol A had undetectable estrogenic activity in MCF-7 cell assays.•Lignin-derivable monomers had reduced estrogenic responses vs. bisphenol A and F.•Developmental toxicity of lignin-derivable monomers was tested for the first time.•Lignin-derivable monomers had minimal developmental toxicity in chicken embryos.
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