The North Tianshan Ocean represents a critical southwestern segment of the Paleo-Asian Ocean and is crucial for understanding accretionary and collisional processes of the southwestern Central Asian Orogenic Belt. The Dananhu arc belt, an important porphyry Cu deposit metallogenic belt in the eastern North Tianshan, records Paleozoic episodic magmatism. However, the tectonic affinity and evolution processes of the Dananhu arc belt are still open to debate. Here, geochronology, major and trace elements, and Sr-Nd-Hf isotope compositions for magmatic rocks are conducted to reveal the ages, petrogenesis, and tectonic settings of these magmatic rocks in the Dannanhu arc belt. The Carboniferous dacite (328 Ma) and gneissic granite (310 Ma) show high-K calc-alkaline, enriched in large ion lithophile elements (LILEs; e.g. Rb, Th, and U), depleted in high field strength elements (HFSEs; e.g. Nb, Ta, and Ti), depleted isotopic compositions (εNd(t) = 1.3-3.4; εHt(t) = 0.5-12.5) and juvenile Nd-Hf model ages. Combining these Carboniferous magmatic rocks with the features of high Sr-Ba granitoid and Sr-Nd isotopic decoupling, we suggest that these Carboniferous rocks were probably formed through fractional crystallization of partial melting of mantle wedge that had been metasomatized by melts from subducted sediments in a forearc setting. The early Permian granites (289-276 Ma) show high K 2 O+Na 2 O (6.9-8.9 wt.%), low MgO (0.06-0.15 wt.%) contents, high positive zircon εHt(t) (10.5 to 12.1) and whole-rock εNd(t) (4.4-5.5) values, suggesting that the early Permian granites were derived from juvenile lower crust in a post-collisional setting. Our geochronological and geochemical data, together with published data, reveal that high flux arc magmatism with age peaks at ca. 431 and 332 Ma is consistent with porphyry copper mineralization in the Dananhu arc belt, implying a close genetic relationship. The final closure of the North Tianshan Ocean was constrained to the late Carboniferous and early Permian.