Display omitted •CFD simulation of droplet formation in a microfluidic T-junction.•Dynamic and constant contact angle models are quantitatively compared.•Using Kistler’s dynamic contact angle model significantly improves the prediction of droplet formation.•The value of the advancing contact angle significantly affects the droplet size. Due to the dominance of interfacial forces, microreactors are commonly applied to multiphase processes where control over the dispersed phase volume is critical. For the design of such microfluidic devices, it is therefore important to accurately predict droplet breakup and the resulting two-phase flow pattern using computational tools. In this work, we show that integrating a dynamic contact angle model into a volume-of-fluid (VOF) solver significantly increases the prediction accuracy of droplet formation in a microfluidic T-junction compared to earlier studies with a constant contact angle model. Furthermore, it was found that the droplet formation is more sensitive to the chosen value of the advancing contact angle, while the receding contact angle showed only a minor influence. The present findings confirm that using a dynamic contact angle model with a VOF approach to simulate droplet formation in microchannels will provide more accurate predictions.