E-resources
Open access
-
Wiyono, Tri; Nisa, Khoirun; Handayani, Sri; Windarsih, Anjar; Hayati, Septi Nur; Wulanjati, Martha Purnami; Sholikhah, Eti Nurwening; Pratiwi, Woro Rukmi
Egyptian Journal of Basic and Applied Sciences, 12/31/2023, Volume: 10, Issue: 1Journal Article
Pancreatitis has the potential to occur with increasing cases of hyperlipidemia and alcohol consumption. Meanwhile, until now pharmacotherapy for pancreatitis is more emphasized for pain relief and lowering triglyceride levels (for HFD-induced pancreatitis). The polyphenol (quercetin) has several biological activities, including anti-cancer, antiallergic, anti-inflammatory and ant-diabetic. This study aimed to evaluate the potential effect of quercetin to treat pancreatitis. After verification, 19 relevant articles were included in the analysis, where Linear mix model analysis was applied to parameters including blood glucose, pancreas islet number, insulin level, TBARS level, nuclear factor kappa B (NF-κB), endogenous antioxidant (GSH, SOD, CAT, GPx), TNFα, IL−6, Caspase 3 (Casp3) and IL−1b gene expression. The level quercetin was used as fixed effect and study setting as random effect. The administration of quercetin was able to significantly increase the production of tissue insulin, restore the antioxidant defense system (increase SOD, GSH, decrease TBARS), and inhibit the progression of inflammation based on the expression of NF-kB, TNFα and IL−6 genes. Therefore, the results of meta-analysis support the hypothesis that quercetin is able to restore pancreatic function, and has the potential to be developed to treat pancreatitis.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.