Alveolar macrophages and type I IFN in airway homeostasis and immunity

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Alveolar macrophages and type I IFN in airway homeostasis and immunity

Divangahi, Maziar; King, Irah L; Pernet, Erwan

Trends in immunology, 05/2015, Volume: 36, Issue: 5

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Highlights • The airways are constantly patrolled by alveolar macrophages. • Alveolar macrophages are indispensable for tissue homeostasis and host defense. • Alveolar macrophages are the major source of type I IFN following immune challenge. • Type I IFNs regulate antimicrobial and inflammatory responses of pulmonary macrophages. • Eicosanoids modulate type I IFN signaling and production following pathogen invasion.

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Divangahi, Maziar | King, Irah L | Pernet, Erwan

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