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Berto, A.; Anh, P. H.; Carrique‐Mas, J. J.; Simmonds, P.; Van Cuong, N.; Van Dung, N.; Woolhouse, M. E.; Smith, I.; Bryant, J. E.; Thwaites, G. E.; Baker, S.; Kiet, Bach Tuan; Boni, Maciej F.; Phu, Bui Duc; Campbell, James I; Hung, Dang Manh; Huong, Dang Thao; Oanh, Dang Tram; Day, Jeremy N.; Doorn, H. Rogier; Han, Duong An; Farrar, Jeremy J; Trang, Hau Thi Thu; Nghia, Ho Dang Trung; Long, Hoang Bao; Van Duong, Hoang; Thu, Huynh Thi Kim; Hung, Manh; Phuong, Thanh; Phuc, Thi; Ha, Luu Thi Thu; Loan, Mai Thi Phuoc; Nadjm, Behzad; Bao, Ngo Thanh; Tu, Nguyen Canh; Thuan, Nguyen Dac; Chuyen, Nguyen Khac; An, Nguyen Ngoc; Vinh, Nguyen Ngoc; Hung, Nguyen Quoc; Dung, Nguyen Thanh; Minh, Nguyen Thanh; Tham, Nguyen Thi Hong; Tien, Nguyen Thi Hong; Chuc, Nguyen Thi Kim; Ngoc, Nguyen Thi; Ha, Nguyen Thi Lien; Lien, Nguyen Thi Nam; Diep, Nguyen Thi Ngoc; Nhung, Nguyen Thi; Chau, Nguyen Thi Song; Chi, Nguyen Thi Yen; Trinh, Nguyen Thieu; Van, Nguyen Thu; Van Kinh, Nguyen; Van Minh Hoang, Nguyen; Van My, Nguyen; Van Thang, Nguyen; Van Thanh, Nguyen; Van Vinh Chau, Nguyen; Van Xang, Nguyen; Khoa, Pham Thi Minh; Tam, Pham Thi Thanh; Van Minh, Pham; Van Be Bay, Phan; Rahman, Motiur; Thompson, Corinne; Ngan, Ta Thi Dieu; Nhu, Tran Do Hoang; Chau, Tran Hoang Minh; Phuc, Tran My; Hong, Tran Thi Kim; Dung, Tran Thi Ngoc; Thanh, Tran Thi Thanh; Minh, Tran Thi Thuy; Nguyen, Tran Thua; Tri, Trinh Quang; Hien, Vo Be; Tai, Vo Nhut; Cuong, Vo Quoc; Phat, Voong Vinh; Huong, Vu Thi Lan; Hang, Vu Thi Ty; Wertheim, Heiman; Bogaardt, Carlijn; Brierley, Liam; Chase‐Topping, Margo; Ivens, Al; Lu, Lu; Rambaut, Andrew; Woolhouse, Mark; Cotten, Matthew; Oude Munnink, Bas B.; Phan, My Vu Tra; Hoek, Lia; Deijs, Martin; Jebbink, Maarten F.; Farsani, Seyed Mohammad Jazaeri; Saylors, Karen; Wolfe, Nathan
Zoonoses and public health, February 2018, Volume: 65, Issue: 1Journal Article
Summary Bats and rodents are being increasingly recognized as reservoirs of emerging zoonotic viruses. Various studies have investigated bat viruses in tropical regions, but to date there are no data regarding viruses with zoonotic potential that circulate in bat and rat populations in Viet Nam. To address this paucity of data, we sampled three bat farms and three wet markets trading in rat meat in the Mekong Delta region of southern Viet Nam. Faecal and urine samples were screened for the presence of RNA from paramyxoviruses, coronaviruses and filoviruses. Paramyxovirus RNA was detected in 4 of 248 (1%) and 11 of 222 (4.9%) bat faecal and urine samples, respectively. Coronavirus RNA was detected in 55 of 248 (22%) of bat faecal samples; filovirus RNA was not detected in any of the bat samples. Further, coronavirus RNA was detected in 12 of 270 (4.4%) of rat faecal samples; all samples tested negative for paramyxovirus. Phylogenetic analysis revealed that the bat paramyxoviruses and bat and rat coronaviruses were related to viruses circulating in bat and rodent populations globally, but showed no cross‐species mixing of viruses between bat and rat populations within Viet Nam. Our study shows that potentially novel variants of paramyxoviruses and coronaviruses commonly circulate in bat and rat populations in Viet Nam. Further characterization of the viruses and additional human and animal surveillance is required to evaluate the likelihood of viral spillover and to assess whether these viruses pose a risk to human health.
