Molecularly targeted cancer therapy: some lessons from the past decade

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Molecularly targeted cancer therapy: some lessons from the past decade

Huang, Min; Shen, Aijun; Ding, Jian; Geng, Meiyu

Trends in pharmacological sciences (Regular ed.), 01/2014, Volume: 35, Issue: 1

Journal Article

Highlights • Tumor heterogeneity is the key factor underlying limited response rate to targeted therapy. • Personalized medicines depend on biomarkers for selecting patients and directing therapy. • Co-development of predictive and response biomarkers is required for drug development. • PDX model-based trials mimicking human patients may improve biomarker discovery.

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Huang, Min | Shen, Aijun | Ding, Jian | Geng, Meiyu

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