Abstract Background There is a perception among Canadian physicians that coronary artery disease (CAD) and adverse cardiac events are more common in those with French Canadian heritage. We sought to compare the prevalence of CAD using coronary computed tomography angiography (CCTA) in French Canadians and non-French Caucasian Canadians. Methods Consecutive patients were prospectively enrolled into our institutional CCTA Registry. Of 10,868 CCTA examinations, we analyzed Caucasian patients who identified themselves as French Canadian or non-French Canadian. These 2 groups were compared for baseline characteristics, cardiovascular risk factors and routine markers for CAD on CTCA. Propensity score adjustments were also made to account for differences in demographics. Results We identified 1,683 French Canadians (mean age 58.5±10.7 years, 54.2% male) and 5,077 non-French Caucasian Canadians (mean age 59.4±11.4 years, 57.3% male). French Canadians were more likely to have smoking history (64.1% vs. 56.1%), diabetes (15.6% vs. 13.6%) and family history of premature CAD (53.3% vs. 44.6%) (p <0.05 for all). There was no significant difference in measures of CAD between French Canadians and non-French Caucasian Canadians in obstructive CAD (32.5% vs. 32.2%, p=0.997), total plaque score (4.6±4.3 vs. 4.5±4.4, p=0.616) and Agatston Score (168.1±319.8 vs. 183.6±433.7, p=0.371). After propensity score adjustment, there was still no significant difference between the groups. Conclusions Our study suggests that French Canadians in the Champlain Region have greater prevalence of cardiovascular risk factors compared to Non-French Canadians, however do not appear to have greater prevalence or severity of CAD or coronary atherosclerosis as assessed by CCTA.