E-resources
Peer reviewed
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Xue, Ting; Zhang, Zongnan; Zeng, Rong
Organic letters, 01/2022, Volume: 24, Issue: 3Journal Article
We report an alkoxy radical process for the C–C bond cleavage and functionalization of unstrained tertiary and secondary cyclic alcohols. In the absence of a chlorine atom, the readily available iron catalysts Fe(OBu-t)3 or Fe(acac)3/t-BuONa facilitate alkoxy radical formation via the direct ligand-to-metal charge transfer of Fe alkoxide and further enable the ring opening and amination of cyclic alcohols. The remote amino carbonyl compounds could be obtained with a broad scope in up to excellent yields under the mildly redox-neutral system. Light-driven electron transfer, alkoxy radical formation, and subsequent C–C bond cleavage via β-scission were the keys to the transformation.
