E-resources
Peer reviewed
Open access
-
Kozawa, Eiji; Nishida, Yoshihiro; Kawai, Akira; Hayakawa, Keiko; Setsu, Nokitaka; Kawashima, Hiroyuki; Iwata, Shintaro; Tsuchiya, Hiroyuki; Tsukushi, Satoshi; Takenaka, Satoshi; Imanishi, Jungo; Baba, Ichiro; Nagano, Akihito; Morii, Takeshi; Shirai, Toshiharu; Shimizu, Koki; Kawano, Hirotaka
Cancer science, July 2022, Volume: 113, Issue: 7Journal Article
Chondrosarcoma is the second most common primary malignant bone tumor. In this multicenter study, we sought to evaluate the disease‐specific survival (DSS) and disease‐free survival (DFS), and prognostic factors in patients with dedifferentiated chondrosarcoma (DDCS) or grade 3 chondrosarcoma (G3CS) in Japan. We retrospectively investigated the treatment outcomes and prognostic factors in 62 patients with DDCS and 19 patients with G3CS at 15 institutions participating in the Japanese Musculoskeletal Oncology Group. We also clarified significant clinicopathological factors for oncological outcomes. In surgery for primary lesions aimed at cure, a histologically negative margin (R0) was obtained in 93% (14/15) of patients with G3CS and 100% (49/49) of patients with DDCS. The 5‐year DSS was 18.5% in patients with DDCS and 41.7% in patients with G3CS (p = 0.13). Local control was obtained in 80% (12/15) and 79.6% (39/49) of patients with G3CS and DDCS in the primary lesion after surgery with a wide surgical margin, respectively. In multivariate analysis, stage and no treatment/palliative treatment for the primary lesion were independent prognostic factors for DSS of DDCS, and age and no treatment/palliative treatment for DSS of G3CS. The 5‐year DFS rate was 22.8% in 26 patients with DDCS who did not receive adjuvant chemotherapy, and 21.4% in 14 patients who received adjuvant chemotherapy. The prognosis of DDCS remains poor, although R0 resection was carried out in most cases. Effective and/or intensive chemotherapeutic regimens or agents should be considered or developed for patients with high‐grade chondrosarcoma, particularly for those with DDCS. This study clarified the clinical outcomes of dedifferentiated chondrosarcoma (DDCS) and grade 3 chondrosarcoma (G3CS) by a nationwide multicenter study in Japan, which is the largest research report from Asian countries. Although all cases (100%) of DDCS and 93% of G3CS underwent surgery with a negative margin (R0), the 5‐year disease‐specific survival was 18.5% in DDCS and 41.7% in G3CS patients.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.