Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

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Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

Morera, Enrico; De Petrocellis, Luciano; Morera, Ludovica; Moriello, Aniello Schiano; Ligresti, Alessia; Nalli, Marianna; Woodward, David F.; Di Marzo, Vincenzo; Ortar, Giorgio

Bioorganic & medicinal chemistry letters, 12/2009, Volume: 19, Issue: 23

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The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some ‘dual-action’ compounds targeting both FAAH and TRPV1 or TRPA1 channels. The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some ‘dual-action’ compounds targeting both FAAH and TRPV1 or TRPA1 receptors.

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