Three reviews summarize immune checkpoint inhibitor (ICI) treatments for colorectal cancer, various aspects of rectal cancer, and pathological consideration of tumor deposits. Because immunotherapy has been established as an additional treatment approach, multimodal therapy has become mainstream for treating gastrointestinal cancers. ...as these patients have a longer disease duration, the number of patients with cancer and dysplasia owing to inflammation is increasing. ...the authors caution that there is a need for care when malignancies are treated with biological agents, especially in older patients (DOI: 10.1002/ags3.12626). ...Ueno et al. have described tumor deposit (TD) categorization in the TNM classification.