E-resources
-
Aglago, Elom K; Mayén, Ana-Lucia; Knaze, Viktoria; Freisling, Heinz; Fedirko, Veronika; Hughes, David J; Jiao, Li; Eriksen, Anne Kirstine; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B; Birukov, Anna; Palli, Domenico; Sieri, Sabina; Santucci de Magistris, Maria; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Derksen, Jeroen W G; Skeie, Guri; Gram, Inger Torhild; Sandanger, Torkjel; Quirós, J Ramón; Luján-Barroso, Leila; Sánchez, Maria-Jose; Amiano, Pilar; Chirlaque, María-Dolores; Gurrea, Aurelio Barricarte; Johansson, Ingegerd; Manjer, Jonas; Perez-Cornago, Aurora; Weiderpass, Elisabete; Gunter, Marc J; Heath, Alicia K; Schalkwijk, Casper G; Jenab, Mazda
Nutrients, 09/2021, Volume: 13, Issue: 9Journal Article
Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N -carboxy-methyllysine (CML), N -carboxyethyllysine (CEL), and N -(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HR . = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HR . = 0.92, 95% CI = 0.85-1.00), but not for CEL (HR . = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.