In a community sample of 102 Portuguese white women we evaluated the relationship between osteoporosis and indexes of psychopathology and well-being. Depressive symptoms were assessed by the Beck Depression Inventory (BDI), psychopathology by the Hopkins Symptom Checklist-90 Revised (SCL-90-R), and quality of life using the Psychological General Well-Being Index. A questionnaire comprising social, demographic, clinical, and behavioral characteristics was also used. The sample prevalence of osteoporosis was 47.1%. Women with osteoporosis presented significantly higher scores on the total BDI 16±9 vs. 13±10, p=0.045 and lower scores in the hostility 0.8±0.6 vs. 1.2±0.7, p=0.012 and phobic anxiety 1.1±0.8 vs. 1.5±0.9, p=0.041 subscales of the SCL-90-R. No differences were found regarding mean general well-being scores 62±17 vs. 64±19, p=0.665 . This study showed that women with osteoporosis have significantly higher levels of depressive symptoms and a corresponding higher prevalence of depression, independent of other factors strongly associated with osteoporosis, such as age or body mass index.