The present work involves the photocatalytic degradation of indole on a recirculating reactor. The effects of various factors as initial concentration of indole, catalyst-loading, pH, agitation and flow rate of the solution on the photodegradation were examined. The experimental results indicate that the optimal pH for indole elimination is about 6-7; the effect of catalyst loading shows an optimal value (1g/L) which is necessary to degrade indole; the increase of recirculating rate leads to a decrease of degradation rate due to the reduction of the residence time; the agitation speed has a slight influence on the indole degradation by improving the mass transfer step. Finally, L-H model was used to fit experimental results concerning the influence of experimental data. L-H model constants' were determined also.