Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx

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Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx

Peppelenbosch, M P; Tertoolen, L G; de Vries-Smits, A M; Qiu, R G; M'Rabet, L; Symons, M H; de Laat, S W; Bos, J L

Journal of biological chemistry/The Journal of biological chemistry, 04/1996, Volume: 271, Issue: 14

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We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.

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