A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features

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A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Bueno, Clara; Torres-Ruiz, Raul; Velasco-Hernandez, Talia; Molina, Oscar; Petazzi, Paolo; Martinez, Alba; Rodriguez, Virginia; Vinyoles, Meritxell; Cantilena, Sandra; Williams, Owen; Vega-Garcia, Nerea; Rodriguez-Perales, Sandra; Segovia, Jose C; Quintana-Bustamante, Oscar; Roy, Anindita; Meyer, Claus; Marschalek, Rolf; Smith, Alastair L; Milne, Thomas A; Fraga, Mario F; Tejedor, Juan Ramón; Menéndez, Pablo

Blood, 2023-Nov-16, Volume: 142, Issue: 20

Journal Article

Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.

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