Uvod: U dostupnoj literaturi populacija studenata izdvaja se iz opće populacije kao zasebna s uočenom nižom razinom kvalitete života u odnosu na opću populaciju. Studije prije pandemije pokazuju da studenti, a poglavito studenti medicine, prijavljuju nižu kvalitetu života tijekom pandemije. Pandemija COVID-19 utjecala je na sve aspekte života, uključujući i kvalitetu života. Cilj ovoga istraživanja bio je procijeniti kvalitetu života studenata Medicinskog fakulteta Sveučilišta u Zagrebu tijekom pandemije COVID-19. Ispitanici i metode: Uzorak ispitanika u ovom istraživanju činilo je 404 studenata medicine (34,4% mladića i 65,6% djevojaka) sa Sveučilišta u Zagrebu, akademske godine 2019./2020. Studenti su ispunili demografski upitnik, upitnik Svjetske zdravstvene organizacije o kvaliteti života-kratka verzija (WHOQOL-BREF) i dodatni upitnik o COVID-19. Rezultati: Studenti medicine, u procjeni kvalitete života, najviše vrijednosti iskazali su u okolišnoj domeni (75,97 ± 15,10),tjelesnoj (69,18 ± 17,79), društvenoj (66,46 ± 21,15),te u psihološkoj domeni (63,11 ± 20,06). Multivarijatna regresijska analiza izdvojila je ženski spol (β= -2,213, p<0,001) i osjećaj zabrinutosti nakon porasta pandemije COVID-19 (β= -2,306, p=0,022) kao prediktore lošijeg tjelesnog funkcioniranja. Nasuprot tome, prediktori boljeg tjelesnog funkcioniranja bili su viša godina studija (β=0,162, p<0,001) i bolja akademska postignuća (β=0,384, p<0,001). Zaključak: Rezultati pokazuju da su studenti medicine procijenili svoju kvalitetu života na početku pandemije COVID-19 dobrom u sve četiri domene. Utjecaj ženskoga spola i više godine studija na tjelesnu i psihološku domenu kvalitete života, upućuju na potrebu razvoja intervencije u specifičnim dijelovima studentske populacije. Introduction: Considering the quality of life, it has been found that students stand out from the generalpopulation as a separate population, with an observed lower level of quality of life compared to the generalpopulation, especially medical students. The COVID-19 pandemic affected all aspects of life, including thequality of life. The aim of this study was to estimate the quality of life of medical students of the Universityof Zagreb during the COVID-19 pandemic.Method and materials: The sample of respondents in this study consists of 404 medical students(34.4% males) from the University of Zagreb, in the academic year 2019/2020. The students filled out ademographic questionnaire, the World Health Organization Quality of Life Questionnaire-Short Version(WHOQOL-BREF), and an additional questionnaire about COVID-19.Results: Medical students, in assessing the quality of life, achieved the highest values in theenvironmental domain (75.97 ± 15.10), followed by the physical domain (69.18 ± 17.79), the social domain(66.46 ± 21.15) and the psychological domain (63.11 ± 20.06). Multivariate regression analysis singled outwomen (β= -2.213, P<0.001), and the feeling of concern after the escalation of the COVID-19 pandemic(β= -2.306, P=0.022) as predictors of poorer physical functioning. In contrast, predictors of better physicalfunctioning were higher years of study (β=0.162, p<0.001) and better academic achievements (β=0.384,P<0.001).Conclusion: The results showed that medical students at the beginning of the COVID-19 pandemicreported their quality of life as good in all four domains. The influence of the female gender and higherstudy years on the physical and psychological domains of quality of life point to the need for thedevelopment of interventions in specific parts of the student population