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Wei, Jia; Stoesser, Nicole; Matthews, Philippa C; Ayoubkhani, Daniel; Studley, Ruth; Bell, Iain; Bell, John I; Newton, John N; Farrar, Jeremy; Diamond, Ian; Rourke, Emma; Howarth, Alison; Marsden, Brian D; Hoosdally, Sarah; Jones, E Yvonne; Stuart, David I; Crook, Derrick W; Peto, Tim E A; Pouwels, Koen B; Eyre, David W; Walker, A Sarah
Nature microbiology, 09/2021, Volume: 6, Issue: 9Journal Article
We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2, seroconversion rates and quantitative antibody levels after a single dose were lower in older individuals, especially in those aged >60 years. Two vaccine doses achieved high responses across all ages. Antibody levels increased more slowly and to lower levels with a single dose of ChAdOx1 compared with a single dose of BNT162b2, but waned following a single dose of BNT162b2 in older individuals. In descriptive latent class models, we identified four responder subgroups, including a 'low responder' group that more commonly consisted of people aged >75 years, males and individuals with long-term health conditions. Given our findings, we propose that available vaccines should be prioritized for those not previously infected and that second doses should be prioritized for individuals aged >60 years. Further data are needed to better understand the extent to which quantitative antibody responses are associated with vaccine-mediated protection.
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