In-vitro phenotypic susceptibility of HIV-1 'non-B' integrase inhibitors naive clinical isolates to dolutegravir and raltegravir

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In-vitro phenotypic susceptibility of HIV-1 'non-B' integrase inhibitors naive clinical isolates to dolutegravir and raltegravir

Charpentier, Charlotte; Bertine, Mélanie; Visseaux, Benoit; Leleu, Juliette; Larrouy, Lucile; Peytavin, Gilles; Mourez, Thomas; Collin, Gilles; Brun-Vézinet, Françoise; Plantier, Jean-C; Descamps, Diane

AIDS, 11/2013, Volume: 27, Issue: 18

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In this study, we assessed phenotypic susceptibility to dolutegravir and raltegravir in a large variety of HIV-1 'non-B' subtypes (n = 72) issued from integrase inhibitor-naive clinical isolates. All samples were susceptible to both dolutegravir and raltegravir with median IC50 values of 1.22 nmol/l and 1.53 nmol/l, respectively; similar to that observed for the B subtype. Thus, despite the high prevalence of polymorphic substitutions in integrase in 'non-B' clinical isolates, phenotypic susceptibility to dolutegravir remained unchanged.

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