Ovarian cancer is the fourth most common gynecological malignancy in Croatia. Reasons for high fatality rates are the rapid growth of cancer and the late presentation of nonspecific symptoms in its advanced stage. Survival rates are significantly improved if cancer is detected early, while still in its localized stage. Screening the general population with the Ca-125 tumor marker and transvaginal ultrasound is not recommended at this time. Although there are no routine diagnostic techniques, early detection of ovarian carcinoma can be significantly improved with early recognition and objectivisation of nonspecific symptoms, analysis of potential biomarkers, as well as the use of multimodal tests.