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Cuccioloni, M; Bonfili, L; Mozzicafreddo, M; Cecarini, V; Pettinari, R; Condello, F; Pettinari, C; Marchetti, F; Angeletti, M; Eleuteri, A. M
RSC advances, 01/2016, Volume: 6, Issue: 46Journal Article
A ruthenium( ii ) p -cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells. A ruthenium( ii ) p -cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition.
