Satellite observation scheduling plays a significant role in improving the efficiency of Earth observation systems. To solve the large-scale multisatellite observation scheduling problem, this article proposes an ensemble of metaheuristic and exact algorithms based on a divide-and-conquer framework (EHE-DCF), including a task allocation phase and a task scheduling phase. In the task allocation phase, each task is allocated to a proper orbit based on a metaheuristic incorporated with a probabilistic selection and a tabu mechanism derived from ant colony optimization and tabu search, respectively. In the task scheduling phase, we construct a task scheduling model for every single orbit and solve the model by using an exact method (i.e., branch and bound, B&B). The task allocation and task scheduling phases are performed iteratively to obtain a promising solution. To validate the performance of the EHE-DCF, we compare it with B&B, three divide-and-conquer-based metaheuristics, and a state-of-the-art metaheuristic. Experimental results show that the EHE-DCF can obtain higher scheduling profits and complete more tasks compared with existing algorithms. The EHE-DCF is especially efficient for large-scale satellite observation scheduling problems.