Personality traits play a crucial role in studying mental disorders because they offer insights into the individual differences and vulnerabilities that influence the onset, course, and treatment of these disorders. Recognizing the significance of personality in mental health research and clinical practice contributes to a more holistic and personalized approach to understanding and managing mental health conditions. Studying the relationship between personality traits and mental disorders can shed light on the underlying mechanisms and etiology of these disorders. It can help researchers identify common genetic, neural, and environmental factors that contribute to both personality traits and mental health conditions. Zebrafish are increasingly used as models for studying various mental disorders, such as anxiety, depression, and autism spectrum disorders. The existence of zebrafish personality traits can help elucidate how different individuals within a population may be more or less susceptible to these conditions. By examining the genetic underpinnings of zebrafish personality traits and their link to mental disorders, researchers can identify potential genetic markers and pathways involved in the pathogenesis of these conditions. Zebrafish research allows for in-depth exploration of the neural and neurochemical mechanisms underpinning personality traits and how these relate to mental disorders. Insights from zebrafish studies can inform our understanding of these mechanisms in more complex organisms. KEYWORDS: Schizophrenia, personality, zebrafish, animal models.