Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

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Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Singh, Sudha B.; Davis, Alexander S.; Taylor, Gregory A.; Deretic, Vojo

Science (American Association for the Advancement of Science), 09/2006, Volume: 313, Issue: 5792

Journal Article

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

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Singh, Sudha B. | Davis, Alexander S. | Taylor, Gregory A. | Deretic, Vojo

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