Hydrogen is one of the most promising options being considered as the fuel of future. However, injection of hydrogen into modern gasoline fueled engines can cause some issues such as power loss. This study, therefore, aims to address this challenge in a simulated hydrogen/gasoline dual-fueled engine by developing a novel and innovative approach without possible side effects such as NOx increment. To achieve this goal, the impacts of water injection and the start of the combustion (SOC) modification in a gasoline/hydrogen duel fueled engine have been rigorously investigated. In current methodology, an engine is simulated using AVL BOOST software and the model is validated against the experimental data. The Latin Hypercube design of experiments method was employed to determine the design points in 3-dimensional space. Due to the existing trade-off between NOx and BMEP, multi-objective optimization using genetic algorithm (GA) was implemented to determine the optimum values of water injection and SOC in various hydrogen energy shares and the effects of optimum design parameters on the main engine performance and emission parameters were investigated. The results showed that the proposed solution could recover the brake mean effective pressure (BMEP) and in some hydrogen energy shares even increase it above the level of single fueled gasoline engine with the added benefit of there being no increase in NOx compared to the original level. Furthermore, other emissions and engine performance parameters are improved including the engine equivalent Brake specific fuel consumption (BSFC) which was shown to increased up to 4.61%. •Water injection and SOC modification improved hydrogen/gasoline engine performance.•BMEP was recovered by optimized SOC and water injection.•Engine BSFC was reduced up to 4.61%.•A significant NOx reduction of up to 59% was achieved.