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Bellanda, Massimo; Mammi, Stefano; Geremia, Silvano; Demitri, Nicola; Randaccio, Lucio; Broxterman, Quirinus B.; Kaptein, Bernard; Pengo, Paolo; Pasquato, Lucia; Scrimin, Paolo
Chemistry : a European journal, 01/2007, Volume: 13, Issue: 2Journal Article
Like shock absorbers in cars short helical peptides rich in C α ‐tetrasubstituted amino acids change their elongation responding to an external stimulus. In fact, they behave like molecular springs and adjust their conformation according to the polarity of the medium in which they are dissolved. In solvents of high polarity (like water) they shrink, adopting an α‐helix conformation, while in solvents of low polarity (like isopropanol) they elongate, adopting a 3 10 ‐helix conformation. Details of this behavior are to be found in the Full Paper by P. Scrimin, S. Mammi, L. Randaccio, L. Pasquato et al. on page 407 ff.
