We introduce two methods to identify false-positive planetary signals in the context of radial-velocity exoplanet searches. The first is the bi-Gaussian cross-correlation function fitting (and monitoring of the parameters derived from it), and the second is the measurement of asymmetry in radial-velocity spectral line information content, Vasy. We assess the usefulness of each of these methods by comparing their results with those delivered by current indicators. We make a systematic analysis of the most used common line profile diagnosis, Bisector Inverse Slope and Velocity Span, along with the two proposed ones. We evaluate all these diagnosis methods following a set of well-defined common criteria and using both simulated and real data. We show that the two indicators discussed here should be considered as standard tests to check for the planetary nature of a radial-velocity signal. We encourage the usage of different diagnosis as a way of characterizing the often elusive line profile deformations.