E-resources
Peer reviewed
-
Qin, Ling; Cao, Junhan; Xu, Hui; Li, Nianxu; Wang, Kai; Zhang, Liping; Qu, Changfeng; Miao, Jinlai
International journal of biological macromolecules, 05/2023, Volume: 236Journal Article
A sulfated polysaccharide from the brown alga Ishige okamurae Yendo, designated IOY, was successfully isolated by anion-exchange and size-exclusion chromatography. Chemical and spectroscopic analyses demonstrated that IOY was a fucoidan, that consisted of →3)-α-l-Fucp-(1→, →4)-α-l-Fucp-(1→, →6)-β-d-Galp-(1 → and →3)-β-d-Galp-(1 → residues with sulfate groups at C-2/C-4 the of (1 → 3)-α-l-Fucp and C-6 the of (1 → 3)-β-d-Galp residues. IOY possessed a potent immunomodulatory effect in vitro as measured by lymphocyte proliferation assay. The immunomodulatory effect of IOY was further investigated in vivo using immunosuppressed mice induced by cyclophosphamide (CTX). The results showed that IOY significantly increased the spleen and thymus indexes and alleviated CTX-induced spleen and thymus damage. Furthermore, IOY had a significant effect on hematopoietic function recovery and promoted the secretion of interleukin-2 (IL-2) and tumor necrosis factor (TNF-α). Notably, IOY reversed CD4+ and CD8+ T cell reduction and improved immune response. These data indicated that IOY had vital in immunomodulatory function and could be used as drug or functional food to lessen chemotherapy-induced immunosuppression.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.