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  • Synthesis and profile of SC...
    Billah, Motasim; Cooper, Nicola; Cuss, Francis; Davenport, Richard J.; Dyke, Hazel J.; Egan, Robert; Ganguly, Ashit; Gowers, Lewis; Hannah, Duncan R.; Haughan, Alan F.; Kendall, Hannah J.; Lowe, Christopher; Minnicozzi, Michael; Montana, John G.; Naylor, Robert; Oxford, Janet; Peake, Joanna C.; Piwinski, John J.; Runcie, Karen A.; Sabin, Verity; Sharpe, Andrew; Shih, Neng-Yang; Warneck, Julie B.H.

    Bioorganic & medicinal chemistry letters, 06/2002, Volume: 12, Issue: 12
    Journal Article

    The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4). The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of PDE4.