E-resources
Peer reviewed
-
Dastidar, Sujata G; Ganguly, Kumkum; Chaudhuri, Keya; Chakrabarty, A.N
International journal of antimicrobial agents, 04/2000, Volume: 14, Issue: 3Journal Article
Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50–100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 μg Dc per 20 g mouse (Swiss Albino variety) significantly ( P <0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 μ Ci ( 3H) deoxythymidine uptake.
