E-resources
Peer reviewed
Open access
-
Brott, Stefan; Thomas, François; Behrens, Maike; Methling, Karen; Bartosik, Daniel; Dutschei, Theresa; Lalk, Michael; Michel, Gurvan; Schweder, Thomas; Bornscheuer, Uwe T.
ChemBioChem, July 19, 2022, Volume: 23, Issue: 14Journal Article
Formaldehyde is a toxic metabolite that is formed in large quantities during bacterial utilization of the methoxy sugar 6‐O‐methyl‐d‐galactose, an abundant monosaccharide in the red algal polysaccharide porphyran. Marine bacteria capable of metabolizing porphyran must therefore possess suitable detoxification systems for formaldehyde. We demonstrate here that detoxification of formaldehyde in the marine Flavobacterium Zobellia galactanivorans proceeds via the ribulose monophosphate pathway. Simultaneously, we show that the genes encoding the key enzymes of this pathway are important for maintaining high formaldehyde resistance. Additionally, these genes are upregulated in the presence of porphyran, allowing us to connect porphyran degradation to the detoxification of formed formaldehyde. The oxidative demethylation of 6‐O‐methyl‐d‐galactose produces formaldehyde. Marine bacteria that utilize this sugar in the degradation of porphyran must therefore possess suitable formaldehyde detoxification pathways. The connection between the degradation of marine carbohydrates and the detoxification of formaldehyde has been demonstrated for the marine model organism Zobellia galactanivorans.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.