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Li, Shuailong; Zhang, Dequan; Zhang, Runtong; Bai, Shao‐Tao; Zhang, Xumu
Angewandte Chemie International Edition, August 15, 2022, Volume: 61, Issue: 33Journal Article
The first rhodium‐catalyzed highly chemo‐, regio‐ and enantioselective hydroformylation of cyclopropyl‐functionalized trisubstituted alkenes affording useful chiral cyclopropyl entities is reported. Compared to generally used diphosphine ligands for asymmetric catalysis, the modified hybrid phosphorus ligand, named (R,S)‐DTBM‐Yanphos, can convert a series of readily available cyclopropyl‐functionalized trisubstituted alkenes into high‐value chiral cyclopropyl‐functionalized aldehydes with high selectivities (81–98 % ee). Gram‐scale reactions (TON up to 1500) and follow‐up transformations to the corresponding alcohol, acid, esters and nitrile are also presented. Finally, a possible hydroformylation mechanism involving ring‐open‐hydroformylation pathways is proposed based on control and deuteroformylation reactions. The first rhodium‐diphosphine‐catalyzed highly chemo‐, regio‐ and enantioselective hydroformylation of cyclopropyl‐functionalized trisubstituted alkenes to afford high‐value chiral cyclopropyl entities is reported. Insights into this transformation were established by control, deuteroformylation, and gram‐scale reactions (TON up to 1500). Versatile follow‐up transformations to the corresponding alcohol, acid, esters and nitrile were also demonstrated.
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