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Wan, Haifeng; He, Zhengquan; Dong, Mingzhu; Gu, Tiantian; Luo, Guan-Zheng; Teng, Fei; Xia, Baolong; Li, Wei; Feng, Chunjing; Li, Xin; Li, Tianda; Shuai, Ling; Fu, Rui; Wang, Liu; Wang, Xiu-Jie; Zhao, Xiao-Yang; Zhou, Qi
Cell research, 11/2013, Volume: 23, Issue: 11Journal Article
Abnormal oocytes are one of the major causes of reproductive failure, and also limit the efficiency of assisted reproduction 1. The generation of functional oocytes either by differentiation of pluripotent stem cells 2 or in vitro culturing of the embryonic genital ridges 3 has not yet been achieved. Recently, we and other groups have reported that live fertile mice could be successfully produced by injecting androgenetic haploid embryonic stem （ahES） cells that carry some paternal imprints into oocytes in place of sperm 4, 5.
