The 3D lip synchronization is one of the hot topics and difficulties in the field of computer graphics. How to carry out 3D lip synchronization effectively and accurately is an important research direction in the field of multimedia. On this basis, a comprehensive weighted algorithm is introduced in this paper to sort out the related laws and the time of lip pronunciation in animation multimedia, carry out the vector weight analysis on the texts in the animation multimedia, and synthesize a matching evaluation model for 3D lip synchronization. At the same time, the goal of simultaneous evaluation can be achieved by synthesizing the transitional mouth pattern sequence between consecutive mouth patterns. The results of the simulation experiment indicate that the comprehensive weighted algorithm is effective and can support the evaluation and analysis of animation multimedia 3D lip synchronization.