E-resources
Peer reviewed
Open access
-
Nakao, Tetsushi; Bick, Alexander G; Taub, Margaret A; Zekavat, Seyedeh M; Uddin, Md M; Niroula, Abhishek; Carty, Cara L; Lane, John; Honigberg, Michael C; Weinstock, Joshua S; Pampana, Akhil; Gibson, Christopher J; Griffin, Gabriel K; Bhattacharya, Romit; Assimes, Themistocles L; Emery, Leslie S; Stilp, Adrienne M; Wong, Quenna; Smith, Albert V; Blackwell, Thomas W; Codd, Veryan; Nelson, Christopher P; Yoneda, Zachary T; Peralta, Juan M; Bowden, Donald W; Wiggins, Kerri L; Gu, C Charles; Peloso, Gina M; Roden, Dan M; Reupena, Muagututi'a S; Hwu, Chii-Min; DeMeo, Dawn L; North, Kari E; Kelly, Shannon; Musani, Solomon K; Lloyd-Jones, Donald M; Johnsen, Jill M; Preuss, Michael; Tracy, Russell P; Qiao, Dandi; Desai, Pinkal; Freedman, Barry I; Tiwari, Hemant K; Chavan, Sameer; Smith, Jennifer A; Smith, Nicholas L; Kelly, Tanika N; Hidalgo, Bertha; Cupples, L Adrienne; Weeks, Daniel E; Hawley, Nicola L; Minster, Ryan L; Deka, Ranjan; de Las Fuentes, Lisa; Raffield, Laura M; Vries, Paul S; Kenny, Eimear E; Rich, Stephen S; Whitsel, Eric A; Cho, Michael H; Shoemaker, M Benjamin; Pace, Betty S; Blangero, John; Palmer, Nicholette D; Shuldiner, Alan R; Barnes, Kathleen C; Abecasis, Gonçalo R; Becker, Lewis C; Heckbert, Susan R; He, Jiang; Post, Wendy; Arnett, Donna K; Vasan, Ramachandran S; Darbar, Dawood; Weiss, Scott T; McGarvey, Stephen T; de Andrade, Mariza; Chen, Yii-Der Ida; Kaplan, Robert C; Meyers, Deborah A; Custer, Brian S; Correa, Adolfo; Psaty, Bruce M; Fornage, Myriam; Manson, JoAnn E; Boerwinkle, Eric; Konkle, Barbara A; Loos, Ruth J F; Rotter, Jerome I; Danesh, John; Samani, Nilesh J; Jaiswal, Siddhartha; Libby, Peter; Ellinor, Patrick T; Pankratz, Nathan; Ebert, Benjamin L; Reiner, Alexander P; Mathias, Rasika A; Do, Ron; Natarajan, Pradeep
Science advances, 2022-Apr-08, Volume: 8, Issue: 14Journal Article
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD. (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus for CHIP in genome-wide association studies. Here, we investigated the relationship between CHIP, LTL, and CAD in the Trans-Omics for Precision Medicine (TOPMed) program ( = 63,302) and UK Biobank ( = 47,080). Bidirectional Mendelian randomization studies were consistent with longer genetically imputed LTL increasing propensity to develop CHIP, but CHIP then, in turn, hastens to shorten measured LTL (mLTL). We also demonstrated evidence of modest mediation between CHIP and CAD by mLTL. Our data promote an understanding of potential causal relationships across CHIP and LTL toward prevention of CAD.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.