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Song, Eunjung; Rajesh, Thangamani; Lee, Bo-Rahm; Kim, Eun-jung; Jeon, Jong-Min; Park, Sung-Hee; Park, Hyung-Yeon; Choi, Kwon-Young; Kim, Yun-Gon; Yang, Yung-Hun; Kim, Byung-Gee
Applied microbiology and biotechnology, 08/2013, Volume: 97, Issue: 15Journal Article
Several reports state that three architectural units, including integration host factor, leucyl aminopeptidase (PepA), and purine regulator, are involved in transcriptional process with RNA polymerase in Escherichia coli . Similarly, Streptomyces species possess the same structural units. We previously identified a protein, Streptomyces integration host factor (sIHF), involved in antibiotic production and sporulation. Subsequently, the function of PepA (SCO2179) was examined in detail. PepA is highly conserved among various Streptomyces spp., but it has not yet been characterized in Streptomyces coelicolor . While it is annotated as a putative leucyl aminopeptidase because it contains a peptidase M17 superfamily domain, this protein did not exhibit leucyl aminopeptidase activity. SCO2179 deletion mutant showed increased actinorhodin production and sporulation, as well as more distinct physiological differences, particularly when cultured on N -acetylglucosamine (GlcNAc) minimal media. The results of two-dimensional gel analysis and reverse transcription PCR showed that the SCO2179 deletion increased protein and mRNA levels of ftsZ , ssgA , and actinorhodin (ACT)-related genes such as actII - ORF4 , resulting in increased actinorhodin production and spore formation in minimal media containing GlcNAc.
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