E-resources
-
Benatti, Fabiana B; Miyake, Cíntia N H; Dantas, Wagner S; Zambelli, Vanessa O; Shinjo, Samuel K; Pereira, Rosa M R; Silva, Maria Elizabeth R; Sá-Pinto, Ana Lúcia; Borba, Eduardo; Bonfá, Eloisa; Gualano, Bruno
Frontiers in immunology, 04/2018, Volume: 9Journal Article
Systemic lupus erythematosus (SLE) patients may show increased insulin resistance (IR) when compared with their healthy peers. Exercise training has been shown to improve insulin sensitivity in other insulin-resistant populations, but it has never been tested in SLE. Therefore, the aim of the present study was to assess the efficacy of a moderate-intensity exercise training program on insulin sensitivity and potential underlying mechanisms in SLE patients with mild/inactive disease. A 12-week, randomized controlled trial was conducted. Nineteen SLE patients were randomly assigned into two groups: trained (SLE-TR, = 9) and non-trained (SLE-NT, = 10). Before and after 12 weeks of the exercise training program, patients underwent a meal test (MT), from which surrogates of insulin sensitivity and beta-cell function were determined. Muscle biopsies were performed after the MT for the assessment of total and membrane GLUT4 and proteins related to insulin signaling Akt and AMP-activated protein kinase (AMPK). SLE-TR showed, when compared with SLE-NT, significant decreases in fasting insulin -39 vs. +14%, = 0.009, effect size (ES) = -1.0 and in the insulin response to MT (-23 vs. +21%, = 0.007, ES = -1.1), homeostasis model assessment IR (-30 vs. +15%, = 0.005, ES = -1.1), a tendency toward decreased proinsulin response to MT (-19 vs. +6%, = 0.07, ES = -0.9) and increased glucagon response to MT (+3 vs. -3%, = 0.09, ES = 0.6), and significant increases in the Matsuda index (+66 vs. -31%, = 0.004, ES = 0.9) and fasting glucagon (+4 vs. -8%, = 0.03, ES = 0.7). No significant differences between SLT-TR and SLT-NT were observed in fasting glucose, glucose response to MT, and insulinogenic index (all > 0.05). SLE-TR showed a significant increase in AMPK Thr 172 phosphorylation when compared to SLE-NT (+73 vs. -12%, = 0.014, ES = 1.3), whereas no significant differences between groups were observed in Akt Ser 473 phosphorylation, total and membrane GLUT4 expression, and GLUT4 translocation (all > 0.05). In conclusion, a 12-week moderate-intensity aerobic exercise training program improved insulin sensitivity in SLE patients with mild/inactive disease. This effect appears to be partially mediated by the increased insulin-stimulated skeletal muscle AMPK phosphorylation. www.ClinicalTrials.gov, identifier NCT01515163.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.