The special series devoted to research on opioid use disorder (OUD) conducted in the National Institute on Drug Abuse Treatment Clinical Trials Network (CTN) and published in Addiction Science and Clinical Practice highlights the tremendous progress that the CTN has made over the past two decades in understanding and improving treatment for OUD. 1 summarizes the history and operations of the CTN, points out the shift in focus from studying OUD treatment solely in specialty substance use disorder treatment programs during the CTN’s early years to its nimble pivot to studying OUD treatment in a variety of health care settings including primary care and specialty care, the Emergency Department, and inpatient hospital wards. Because OUD often first manifests in adolescence or early adulthood, Bagley et al. ...as noted in passing above, we cannot ignore the fact that this series, while planned prior to any inkling of the appearance of a worldwide pandemic, was published at the height of the COVID-19 pandemic which colors every aspect of research on and treatment of OUD.