Progranulin: at the interface of neurodegenerative and metabolic diseases

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Progranulin: at the interface of neurodegenerative and metabolic diseases

Nguyen, Andrew D; Nguyen, Thi A; Martens, Lauren Herl; Mitic, Laura L; Farese, Robert V

Trends in endocrinology and metabolism, 12/2013, Volume: 24, Issue: 12

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Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum progranulin levels. • Grn −/− mice are protected from diet-induced obesity and insulin resistance.

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Nguyen, Andrew D | Nguyen, Thi A | Martens, Lauren Herl | Mitic, Laura L | Farese, Robert V

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