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Grodin, Justin L., MD; Lala, Anuradha, MD; Stevens, Susanna R., MS; DeVore, Adam D., MD; Cooper, Lauren B., MD; AbouEzzeddine, Omar F., MD, CM; Mentz, Robert J., MD; Groarke, John D., MBBCh, MPH; Joyce, Emer, MBBCh, PhD; Rosenthal, Julie L., MD; Vader, Justin M., MD; Tang, W.H. Wilson, MD
Journal of cardiac failure, 11/2016, Volume: 22, Issue: 11Journal Article
Highlights • Binding of albumin to diuretics are key to delivery to the nephron, and low albumin levels diminish intravascular oncotic pressures necessary to maintain intravascular volume for effective diuresis. • Based on prospectively collected data from two acute heart failure clinical trials (DOSE-AHF and ROSE-AHF), this may not be the case in acute heart failure populations largely free of nephrotic syndrome or cirrhosis. • Our data from two well characterized cohorts of patients with acute heart failure suggest that serum albumin may not be a helpful tool to guide decongestion strategies or determine effectiveness of therapy.
