E-resources
-
Johansson, Henrik J; Socciarelli, Fabio; Vacanti, Nathaniel M; Haugen, Mads H; Zhu, Yafeng; Siavelis, Ioannis; Fernandez-Woodbridge, Alejandro; Aure, Miriam R; Sennblad, Bengt; Vesterlund, Mattias; Branca, Rui M; Orre, Lukas M; Huss, Mikael; Fredlund, Erik; Beraki, Elsa; Garred, Øystein; Boekel, Jorrit; Sauer, Torill; Zhao, Wei; Nord, Silje; Höglander, Elen K; Jans, Daniel C; Brismar, Hjalmar; Haukaas, Tonje H; Bathen, Tone F; Schlichting, Ellen; Naume, Bjørn; Luders, Torben; Borgen, Elin; Kristensen, Vessela N; Russnes, Hege G; Lingjærde, Ole Christian; Mills, Gordon B; Sahlberg, Kristine K; Børresen-Dale, Anne-Lise; Lehtiö, Janne
Nature communications, 04/2019, Volume: 10, Issue: 1Journal Article
In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Proteome-based networks distinguish functional protein modules for breast tumor groups, with co-expression of EGFR and MET marking ductal carcinoma in situ regions of normal-like tumors and lending to a more accurate classification of this poorly defined subtype. Genes included within prognostic mRNA panels have significantly higher than average mRNA-protein correlations, and gene copy number alterations are dampened at the protein-level; underscoring the value of proteome quantification for prognostication and phenotypic classification. Furthermore, protein products mapping to non-coding genomic regions are identified; highlighting a potential new class of tumor-specific immunotherapeutic targets.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.