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Pardi, Norbert; Carreño, Juan Manuel; O'Dell, George; Tan, Jessica; Bajusz, Csaba; Muramatsu, Hiromi; Rijnink, Willemijn; Strohmeier, Shirin; Loganathan, Madhumathi; Bielak, Dominika; Sung, Molly M H; Tam, Ying K; Krammer, Florian; McMahon, Meagan
Nature communications, 08/2022, Volume: 13, Issue: 1Journal Article
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high capacity for rapid development. Generation of a universal influenza virus vaccine with the potential to elicit long-lasting, broadly cross-reactive immune responses is a necessity for reducing influenza-associated morbidity and mortality. Here we focus on the development of a universal influenza B virus vaccine based on the lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform. We evaluate vaccine candidates based on different target antigens that afford protection against challenge with ancestral and recent influenza B viruses from both antigenic lineages. A pentavalent vaccine combining all tested antigens protects mice from morbidity at a very low dose of 50 ng per antigen after a single vaccination. These findings support the further advancement of nucleoside-modified mRNA-LNPs expressing multiple conserved antigens as universal influenza virus vaccine candidates.
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