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Al-Ghamdi, Alwah R; Rahman, Shofiur; Al-Wabli, Reem I; Al-Mutairi, Maha S; Rahman, A F M Motiur
Molecules (Basel, Switzerland), 04/2024, Volume: 29, Issue: 8Journal Article
In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, - ), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. The fluorescence spectra of the synthesized - in different solvents reveal solvent-dependent shifts in the emission maximum values, highlighting the influence of the solvent environment on their fluorescence properties. A quantum chemical TD-DFT analysis provides insights into the electronic structure and fluorescence behavior of - , elucidating HOMO-LUMO energy gaps, electronegativity values, and dipole moments, contributing to a deeper understanding of their electronic properties and potential reactivity. These findings provide valuable knowledge for the development of APNs ( - ) as fluorescent sensors and potential anticancer agents.
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