The RATIOnal Role of Polyamines in Epidermal Differentiation

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The RATIOnal Role of Polyamines in Epidermal Differentiation

Allmeroth, Kira; Denzel, Martin S.

Journal of investigative dermatology, September 2021, 2021-09-00, 20210901, Volume: 141, Issue: 9

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Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et al. (2021) report that keratinocyte differentiation requires a shift in polyamine ratios that is mediated by AMD1. Results suggest that targeting polyamine availability might be useful in the treatment of hyperproliferative skin disorders.

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Allmeroth, Kira | Denzel, Martin S.

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