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Tomasetti, Cristian; Vogelstein, Bert
PloS one, 05/2017, Volume: 12, Issue: 5Journal Article
Little et al. 1 misrepresent our findings 2 by making incorrect statements that are similar to those previously found in some media. The problem with these types of statements has been already pointed out by others 3. Specifically, the authors at times confuse the concept of absolute risk with that of relative risk. We never suggested that “most cancers arose by chance”-as stated in the first sentence of the Abstract of 1. Instead, we stated that the variation in cancer risk is largely explained by stem cell divisions 2. We interpreted this correlation as indicating that replicative mutations associated with stem cell divisions (bad luck) was largely responsible for this variation.
