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Słomian, Dawid; Szyda, Joanna; Dobosz, Paula; Stojak, Joanna; Michalska-Foryszewska, Anna; Sypniewski, Mateusz; Liu, Jakub; Kotlarz, Krzysztof; Suchocki, Tomasz; Mroczek, Magdalena; Stępień, Maria; Sztromwasser, Paweł; Król, Zbigniew J
PloS one, 01/2023, Volume: 18, Issue: 1Journal Article
Undoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations. The majority of variants were synonymous (60.56% for severe, 58.46% for resistant phenotype) or located in introns (55.77% for severe, 59.83% for resistant phenotype). We identified the most significant SNPs for a severe outcome (in AJAP1 intron) and for COVID resistance (in FIG4 intron). We found no missense variants with a potential causal function on resistance to COVID-19; however, two missense variants were determined as significant a severe phenotype (in PM20D1 and LRP4 exons). None of the aforementioned SNPs and missense variants found in this study have been previously associated with COVID-19.
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